About Oxidative Stress in Diabetic Complications
Oxidative Stress in Diabetic Complications
About this Collection
This collection has now closed to submissions.
Diabetes can lead to oxidative stress in the human body, which causes various structural and functional changes of the heart, including cardiomyopathy and arrhythmia which can lead to both microvascular and cardiovascular complications. Although many pathophysiological changes occur due to metabolic disorders caused by hyperglycemia, insulin resistance, and dyslipidemia, oxidative stress may be the pivotal pathogenesis responsible for all consequent pathogenic changes, leading to the remodelling and dysfunction. Free fatty acids can stimulate oxidation and accumulate in the cytosol, leading to lipotoxicity by forming ceramides, diacylglycerol, and reactive oxygen species. Hyperglycemia also causes an increase in the content of reactive oxygen species and the formation of advanced glycation end products, which is accompanied by the development of cardiac glucotoxicity. Cardiomyocyte death induced by the lipotoxicity and glucotoxicity is an important pathogenic result that causes pathogenic responses in the rest cells, leading to the remodelling and dysfunction. Therefore, this special issues will focus on the oxidative stress and cell death, which will include several mechanisms and signalling pathways.
Keywords: Diabetic cardiomyopathy, oxidative stress, myocyte death, cardiac remodelling,
Submission deadline: 25th August 2022
Any questions about this collection? Please get in contact directly with Amy Joint (amy.joint@f1000.com)
Diabetes can lead to oxidative stress in the human body, which causes various structural and functional changes of the heart, including cardiomyopathy and arrhythmia which can lead to both microvascular and cardiovascular complications. Although many pathophysiological changes occur due to metabolic disorders caused by hyperglycemia, insulin resistance, and dyslipidemia, oxidative stress may be the pivotal pathogenesis responsible for all consequent pathogenic changes, leading to the remodelling and dysfunction. Free fatty acids can stimulate oxidation and accumulate in the cytosol, leading to lipotoxicity by forming ceramides, diacylglycerol, and reactive oxygen species. Hyperglycemia also causes an increase in the content of reactive oxygen species and the formation of advanced glycation end products, which is accompanied by the development of cardiac glucotoxicity. Cardiomyocyte death induced by the lipotoxicity and glucotoxicity is an important pathogenic result that causes pathogenic responses in the rest cells, leading to the remodelling and dysfunction. Therefore, this special issues will focus on the oxidative stress and cell death, which will include several mechanisms and signalling pathways.
Keywords: Diabetic cardiomyopathy, oxidative stress, myocyte death, cardiac remodelling,
Submission deadline: 25th August 2022
Any questions about this collection? Please get in contact directly with Amy Joint (amy.joint@f1000.com)
Collection Advisor
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Lu Cai
