About Neuroinflammation
Neuroinflammation
About this Collection
This collection is now closed to submissions.
Neuroinflammation – defined as inflammatory responses that are centralised within the central nervous system (CNS) – has classically been implicated in traumatic brain injury (TBI) and stroke, and autoimmune neurological disorders such as Multiple Sclerosis (MS).
Recent advances have revealed clear associations between neuroinflammation and neurodegenerative disease. Increased levels of inflammatory markers are observed in Alzheimer’s Disease (AD) patients, and AD risk genes have been associated with innate immune functions. This is further complicated by the links between infectious disease and neurodegeneration, highlighted by the recent discovery of the causal links between Epstein-Barr Virus (EBV) and MS. Moreover, public attention has been drawn towards neuroinflammation related to emergent viruses such as Sars-CoV-2, which in even mild infections has been found to cause many neurological sequelae.
Caused by autoimmunity, brain injury, infection, or otherwise, neuroinflammation has been associated with development, aging, cognition and beyond. New mechanisms of neuroinflammation are continuously being discovered, roles of key players such as astrocytes are being expanded, and bi-directional links such as the gut-brain axis have renewed interest in the field and the potential for new therapies. However, there are many outstanding questions, and the interplay between the CNS and the immune system remains complex.
This collection invites contributions from a variety of scholars across the globe, that aim to advance our understanding of the cellular and molecular aspects of neuroinflammation.
Topics include (but are not limited to):
This collection is part of the Cell & Molecular Biology Gateway.
Please note that all articles submitted to this collection are subject to F1000's standard editorial and publishing policies.
Submission deadline: 9th November 2023.
Any questions about this collection? Please get in contact directly with Maxine Dillon (maxine.dillon@F1000.com).
Image: Contributor: BSIP SA / Alamy Stock Photo. Microglial cells (green) engulf and remove prion-damaged photoreceptors (red).
Neuroinflammation – defined as inflammatory responses that are centralised within the central nervous system (CNS) – has classically been implicated in traumatic brain injury (TBI) and stroke, and autoimmune neurological disorders such as Multiple Sclerosis (MS).
Recent advances have revealed clear associations between neuroinflammation and neurodegenerative disease. Increased levels of inflammatory markers are observed in Alzheimer’s Disease (AD) patients, and AD risk genes have been associated with innate immune functions. This is further complicated by the links between infectious disease and neurodegeneration, highlighted by the recent discovery of the causal links between Epstein-Barr Virus (EBV) and MS. Moreover, public attention has been drawn towards neuroinflammation related to emergent viruses such as Sars-CoV-2, which in even mild infections has been found to cause many neurological sequelae.
Caused by autoimmunity, brain injury, infection, or otherwise, neuroinflammation has been associated with development, aging, cognition and beyond. New mechanisms of neuroinflammation are continuously being discovered, roles of key players such as astrocytes are being expanded, and bi-directional links such as the gut-brain axis have renewed interest in the field and the potential for new therapies. However, there are many outstanding questions, and the interplay between the CNS and the immune system remains complex.
This collection invites contributions from a variety of scholars across the globe, that aim to advance our understanding of the cellular and molecular aspects of neuroinflammation.
Topics include (but are not limited to):
- The roles of immune and neuroinflammatory mediators in health and disease
- Regeneration and repair mechanisms in the brain, e.g., in traumatic brain injury, stroke
- Autoimmunity, e.g., MS, autoimmune encephalitis
- Age-related immune signatures in the brain, e.g., in ‘inflammageing’
- Neuroinflammation in psychiatry – links to depression, anxiety, stress
- Impacts on cognition, learning and memory
- Implication in neurodegenerative diseases such as AD, Parkinson’s Disease, Amyotrophic Lateral Sclerosis, vascular dementia, MS, and links with infectious disease
- Neuroinflammation in early life and development
- Bi-directional connections such as the gut-brain axis
- Therapies and treatments.
This collection is part of the Cell & Molecular Biology Gateway.
Please note that all articles submitted to this collection are subject to F1000's standard editorial and publishing policies.
Submission deadline: 9th November 2023.
Any questions about this collection? Please get in contact directly with Maxine Dillon (maxine.dillon@F1000.com).
Image: Contributor: BSIP SA / Alamy Stock Photo. Microglial cells (green) engulf and remove prion-damaged photoreceptors (red).